Ibuprofen structure - Ibuprofen

Glycerol was not very effective in increasing the aqueous solubilities of both compounds, whereas sorbitol solution had a minimal effect MedChem Express.

Journal of the American Academy of Dermatology.

The synthesis of ibuprofen was originally reported in 1964 from ρ-isobutyl- lacetophen but the drug was not marketed in the United States until 1974 despite the fact that it had been available for several years in Europe.

Interestingly enough, the body has an enzyme that is able to convert the R- isomer of ibuprofen to the S+ isomer.