The incidence and associated mortality and morbidity rates of severe sepsis are commonly underestimated.
Although there is no single clinical manifestation or laboratory value that is diagnostic of DIC, the following changes are reasonably consistent with the diagnosis: 1 presence of a disorder such as severe sepsis that is known to be linked with DIC, 2 musculocutaneous bleeding and dysfunction of one or more organ systems, and 3 ongoing consumption of coagulation factors.
An aggregate of clinical studies suggests that a circulating myocardial depressant factor, not global myocardial ischemia, is a major contributor to myocardial dysfunction in patients with severe sepsis.