Nano Mesa replaces José Mari.
Cadiz have lost just three games since appointing Sergio, who has racked up four wins and four draws, boosting from relegation favourites to giving them a concrete chance of playing top-flight football next season.
They were also winless in 11 of their past 14 overall fixtures, and they have won just once in their last nineteen appearances at home.
Sergio Asenjo started in goal, with Pau Torres and Aissa Mandi as the centre backs ahead of him.
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Jackson 1 Disciplinary Cadiz Pts Juan Torres Ruiz 7 1 0 9 V.