Data are means ± s.
The final concentration of protein and ligand were 100 and 200 µM, respectively.
Posing a ring constraint to the branched isopropyl group that is the cyclopropyl carboxamide presented in 12 improved the potency compared with 11, but still demonstrated only moderate to weak potency in most cases.
Additional information, resources and reagents will be made available upon reasonable request; requests should be directed to and will be fulfilled by the lead contact M.
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Spectra recorded at pH 7.