Their teammates Fabio Quartararo and Francesco Bagnaia will line up fifth and sixth on the grid respectively.
The first two rounds will now be held in Qatar followed by round three in Portimao.
Citizens of Spain, Italy, and the United Kingdom, for example, are not permitted to enter unless they have a Malaysian residence.
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While the rich protected the grand prix for years, the local government was no longer able to host the race at the venue.
It will be his 329th grand prix, making him the rider with most grand prix starts in the 67-year history of the motorcycling world championship series.