Spinazzola had made more dribbles than any other Italy player and also ranked highly for shots and chances created, but there is no like-for-like replacement in Mancini's squad.
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A confidence-building penalty shootout victory over Switzerland in the last eight could also be vital ahead of the semis.
Live stream world-class sport with Showmax Pro, including every spectacular tackle and save of the Euro 2020 games.
It may not be surprising to discover that opera originated in Italy! Spain 4-3-3 Unai Simon; Cesar Azpilicueta, Eric Garcia, Aymeric Laporte, Jordi Alba; Pedri, Sergio Busquets c , Koke; Mikel Oyarzabal, Ferran Torres, Dani Olmo.
The 28-year-old was enjoying a spectacular tournament, his speed and trickery providing an invaluable outlet on Italy's left flank.